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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
27.88
Human Site:
Y850
Identified Species:
43.81
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
Y850
I
M
Y
E
E
T
T
Y
S
K
K
K
I
I
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
Y850
I
M
Y
E
E
T
T
Y
S
K
K
K
I
I
D
Dog
Lupus familis
XP_531814
1283
145094
N819
V
I
T
L
Q
T
K
N
P
E
G
R
F
P
D
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
Y847
I
M
Y
E
E
T
T
Y
S
K
K
K
I
I
D
Rat
Rattus norvegicus
XP_002726765
1361
151628
Y850
I
M
Y
E
E
T
T
Y
S
K
K
K
I
I
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
Y956
I
F
Y
E
E
I
K
Y
S
K
K
K
I
A
D
Frog
Xenopus laevis
NP_001089247
1340
149481
Y830
V
M
Y
E
E
I
T
Y
S
K
K
K
I
A
D
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
Y851
I
L
Y
E
E
V
V
Y
S
K
R
K
I
A
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
G734
I
T
Q
L
P
E
S
G
G
S
F
P
D
L
S
Honey Bee
Apis mellifera
XP_392346
1120
127429
L664
D
V
L
K
I
I
A
L
F
E
D
F
C
S
T
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
L730
G
C
E
L
L
D
E
L
L
G
N
E
Q
E
M
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
Y822
I
F
F
E
D
A
V
Y
S
K
R
K
I
S
D
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
H824
N
S
G
R
I
I
P
H
E
G
V
D
V
E
Y
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
K812
L
Y
E
D
T
A
K
K
Q
V
Q
E
F
I
S
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
D786
R
G
F
D
I
E
F
D
K
S
M
D
R
I
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
13.3
N.A.
100
100
N.A.
N.A.
73.3
80
66.6
N.A.
6.6
0
0
53.3
P-Site Similarity:
100
N.A.
100
46.6
N.A.
100
100
N.A.
N.A.
73.3
86.6
80
N.A.
20
20
6.6
73.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
14
7
0
0
0
0
0
0
20
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
7
0
0
14
7
7
0
7
0
0
7
14
7
0
60
% D
% Glu:
0
0
14
54
47
14
7
0
7
14
0
14
0
14
0
% E
% Phe:
0
14
14
0
0
0
7
0
7
0
7
7
14
0
0
% F
% Gly:
7
7
7
0
0
0
0
7
7
14
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
54
7
0
0
20
27
0
0
0
0
0
0
54
40
0
% I
% Lys:
0
0
0
7
0
0
20
7
7
54
40
54
0
0
0
% K
% Leu:
7
7
7
20
7
0
0
14
7
0
0
0
0
7
0
% L
% Met:
0
34
0
0
0
0
0
0
0
0
7
0
0
0
7
% M
% Asn:
7
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% N
% Pro:
0
0
0
0
7
0
7
0
7
0
0
7
0
7
0
% P
% Gln:
0
0
7
0
7
0
0
0
7
0
7
0
7
0
7
% Q
% Arg:
7
0
0
7
0
0
0
0
0
0
14
7
7
0
0
% R
% Ser:
0
7
0
0
0
0
7
0
54
14
0
0
0
14
14
% S
% Thr:
0
7
7
0
7
34
34
0
0
0
0
0
0
0
7
% T
% Val:
14
7
0
0
0
7
14
0
0
7
7
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
47
0
0
0
0
54
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _